Chapter 10 Actvity-based analysis

The driver activity estimation is one of the most important features of scMINER. Mathematically, the activity of one driver is a type of mean of the expressions of its targets. And biologically, the activity can be interpreted as a measure that describes how actively the driver functions, like the enzymes in digesting their subtracts, kinase in activating their downstream genes. Given the gene expression profiles and networks, scMINER can estimate the activities of some predefined drivers, including not only transcription factors (TFs) but also signaling genes (SIGs). scMINER provides a few functions to effortlessly calculate the activities, identify the hidden drivers and visualize them in multiple ways.